Lou Gehrig's disease is a disorder that's also called amyotrophic lateral
sclerosis (say: ah-my-uh-TRO-fik LA-tuh-rul skluh-RO-sis), or ALS. The official
name comes from these Greek words:
"a" for without
"myo" for muscle
"trophic" for nourishment
"lateral" for side (of the spinal cord)
"sclerosis" for hardening or scarring
So, amyotrophic means that the muscles have lost their nourishment.
When this happens, they become smaller and weaker. Lateral means
that the disease affects the sides of the spinal cord, where the nerves that nourish
the muscles are located; and sclerosis means that the diseased part
of the spinal cord develops hardened or scarred tissue in place of healthy nerves.
It's called Lou Gehrig's disease after Lou Gehrig, a hall-of-fame baseball player
for the New York Yankees who was diagnosed with ALS in the 1930s.
What Happens in ALS?
ALS damages motor
neurons in the brain and spinal cord. Motor
neurons are nerve cells that control muscle movement. Upper motor neurons send messages from
the brain to the spinal cord, and lower motor
neurons send messages from the spinal cord
to the muscles. Motor neurons are an important part of the body's neuromuscular system.
The neuromuscular system lets our bodies move and is made up of the brain, many
nerves, and muscles. Things that we do every day — like breathing, walking,
running, lifting stuff, and even reaching for a glass of water — are all controlled
by the neuromuscular system.
Over time, ALS causes the motor neurons in the brain
and spinal cord to shrink and disappear, so that the muscles no longer receive signals
to move. So, the muscles get smaller and weaker. Gradually the body becomes paralyzed,
which means that the muscles no longer work.
However, someone with ALS, even at an advanced stage, can still see, hear, smell,
and feel touch. The nerves that carry feelings of hot, cold, pain, pressure, or even
being tickled, are not affected by Lou Gehrig's disease. In some
people with ALS, the parts of the brain that allow us to think, remember, and learn
also are affected by the disease.
Who Gets ALS?
Although this disease can strike anyone, ALS is extremely rare in kids. According
to the ALS Association, most people who develop it are adults between 40 and 70. Only
2 out of every 100,000 people will get the disease each year. It's not contagious,
so you can't catch ALS from someone who has it.
How Is ALS Diagnosed?
Lou Gehrig's disease is different for every person who has it. In general, muscle
weakness, especially in the arms and legs, is an early symptom for more than half
of people with ALS. Other early signs are tripping or falling a lot, dropping things,
having difficulty speaking, and cramping or twitching of the muscles. As the disease
gets worse over time, eating, swallowing, and even breathing may become difficult.
It may take several months to know for sure that someone has Lou Gehrig's disease.
The illness can cause symptoms similar to other diseases that affect nerves and muscles,
including Parkinson's disease and stroke. A doctor will examine the patient and do
special tests to see if it might be one of those other disorders.
One of the tests, an electromyogram (say: eh-lek-tro-MY-uh-gram), or EMG, can show
that muscles are not working because of damaged nerves. Other tests include X-rays,
magnetic resonance imaging (MRI), a spinal tap, and blood and urine evaluations.
Sometimes a muscle or nerve biopsy is needed. A biopsy is when a doctor takes a
tiny sample of tissue from the body to study under a microscope. Examining this tissue
can help the doctor figure out what's making someone sick.
How Is ALS Treated?
Currently, there's no way to prevent or cure Lou Gehrig's disease. But treatments
are available that can help. Medicines can control symptoms, such as muscle cramping
and difficulty swallowing, and other drugs can slow the development of the disease.
Physical therapy can help people with ALS cope with muscle loss and breathing problems.
Special equipment is also provided when it becomes necessary. For instance, a power
wheelchair can let a paralyzed person with ALS get around. A machine called a ventilator
(say: VEN-ti-lay-ter) can help someone breathe.
Also, a nurse or other health assistant may come to the person's home to provide
care that the family cannot handle alone.
Living With Lou Gehrig's Disease
Living with Lou Gehrig's disease is physically difficult,
but it is reassuring to know that the mind usually is not affected. Most people with
ALS can think as clearly as ever, are able to maintain relationships with friends
and family, and should be treated respectfully and normally.
It's normal for family members to feel upset, overwhelmed, and sad if a loved one
has ALS. Counseling, as well as support from other family members and friends, can
make it easier to deal with the challenges they face.
Communication can be difficult because the disease affects breathing and the muscles
needed for speech and arm movement. With patience, the families of patients with ALS
can learn to communicate effectively with their loved one.
Researchers continue to study ALS as they try to understand why it happens, and
how the disease damages the motor neurons in the brain and spinal cord. As they learn
more about the disease, researchers can continue to develop new and better treatments.