What Are the Signs & Symptoms of Becker Muscular Dystrophy?
Becker MD symptoms can range from mild to almost as severe as the symptoms of Duchenne
A child with Becker MD may start to walk later than most kids do. But the disease
rarely causes health problems until a child has muscle weakness in the hips and pelvis.
This usually happens when kids are 10–13 years old. Walking problems are usually
noticed around age 15–16.
A child with Becker MD may:
have more difficulty with sports
have trouble climbing stairs
not be able to walk quickly, run smoothly, or maintain a running pace
have trouble lifting heavy loads
have calf muscles that look bigger than normal, even though they're weaker
Becker MD affects the muscles of the hips, pelvis, thighs, and shoulders, as well
as the heart. Changes in the heart muscle may happen faster than in other muscles.
Children who first show symptoms of Becker MD at younger ages are more likely to have
heart problems than kids whose symptoms start later.
Becker MD is progressive, meaning problems get worse with age. Symptoms gets worse
slowly compared with Duchenne MD. Breathing muscles tend to stay strong enough that
a ventilator or other mechanical breathing help isn't needed.
What Causes Becker Muscular Dystrophy?
In Becker MD, muscles weaken because dystrophin (dis-TRO-fin), a protein made by
muscle cells, doesn't work as it should. A change in the dystrophin gene makes the
protein too short. The flawed dystrophin puts muscle cells at risk for damage with
Usually, the body will repair or replace damaged muscle cells. But in Becker MD,
the cells die instead. After the muscle cells die, they are replaced by fat and scar
Who Gets Becker Muscular Dystrophy?
Among children with the Becker MD gene, boys are most affected with weakness in
their arm and leg movements. That's because the dystrophin gene is on the X chromosome.
Boys have only one X chromosome, but girls have two. So girls almost always have a
second copy of the gene that can make the full, working dystrophin protein. Girls
can be carriers and are at risk of passing this on to their children. Girls can also
have symptoms, but in general they are less severe than in boys.
Both boys and girls with a Becker MD gene can have heart problems.
Most children with a faulty dystrophin gene get it from the mother, who may carry
the faulty gene without knowing it. In some children, the faulty gene is a new genetic
change called a mutation or variation.
How Is Becker Muscular Dystrophy Diagnosed?
Doctors often diagnose muscular dystrophy based on the child's family history,
symptoms, and an exam.
These tests confirm the diagnosis and determine the type of muscular dystrophy:
Creatine kinase (CK) level: This blood test checks the level
of creatine kinase, a protein that normally stays inside muscle cells. When muscular
dystrophy damages muscle cells, they release CK into the blood.
Muscle biopsy: This test can show whether the muscle has any
dystrophin. If there's no dystrophin around the muscle fibers, it usually means the
child has Duchenne MD. Patchy, reduced amounts of dystrophin around the muscle fibers
usually mean the child has Becker MD. The doctor does the biopsy
by removing a small piece of muscle, usually from the thigh.
testing: This will show if there is a missing piece (deletion), duplication,
or a point mutation in the dystrophin gene, which disrupts how the gene works. This
helps the medical team decide how to treat the problem and know what to expect in
How Is Becker Muscular Dystrophy Treated?
There's no cure yet for Becker MD. Treatment is a combination of:
slowing the disease and assisting the heart using medicines
helping the child move around using braces and other physical aids
A child with Becker MD usually is cared for by a team of doctors and other experts
from several pediatric specialties.
What Can I Expect?
Kids with Becker MD can live long, active lives, and research to improve treatment
Some people with Becker MD begin using a wheelchair in their twenties. But many
over age 50 can walk without help or by using a cane, crutches, or walker.
Becker MD does not affect muscles of the bowel and bladder or sexual function.
What Else Should I Know?
If the mother and any sisters of a child with Becker MD are found to be a carrier,
they should have regular visits with a cardiologist (a doctor who specializes in heart
Children with muscular dystrophy may have a harmful response to anesthesia.
If your child must have surgery, make sure the anesthesiologist is aware of the MD.
counseling should be a consideration for any adult with a Becker MD gene before