Stem Cell Transplantsenteenshttps://kidshealth.org/EN/images/headers/P-stemCell-enHD-AR2.jpgStem cells can develop into cells with different skills, so they're useful in treating diseases like cancer.stem cells, bone marrow, transplant, blood, donor, donate, cord, umbilical, blood, neutropenia, hematopoietic stem cells, autologous transplants, allogeneic transplants, WBCs, white blood cells, red blood cells, platelets, umbilical cord blood, cancer, immune system, leukemia, lymphoma, graft-versus-host disease, neuroblastoma, wilms tumor, lupus, sickle cell, thalassemia, hematology, transplantation, infusion, rejection, cancer center, transplants, donors, blood cells, grafting, cancers, treating cancer, cancer treatments, leukemia, lookemia, luykemia, luekemia, testicular cancers, ovarian cancers, blood disorders, immune system diseases, hematopoietic, umbilical cord blood, cord blood, autologous, allogeneic08/14/200909/12/201909/12/2019Amy W. Anzilotti, MD09/09/201928245333-8896-4baf-a82f-dd5000213e7dhttps://kidshealth.org/ws/RadyChildrens/en/teens/stem-cells.html/<h3>What Is a Stem Cell Transplant?</h3> <p>A stem cell transplant is when doctors put healthy stem cells into someone's bloodstream to replace their stem cells.</p> <p>It can take a while to feel better after a stem cell transplant, but the treatment can be very helpful for some illnesses.</p> <h3>What Are Stem Cells?</h3> <p>Stem cells are cells that can develop into many different types of cells. The stem cells used for transplants form blood cells. They become:</p> <ul> <li><strong>red blood cells</strong> that carry oxygen</li> <li><strong>white blood cells</strong> that fight infection</li> <li><strong>platelets</strong> that help blood clot</li> </ul> <h3>Why Are Stem Cell Transplants Done?</h3> <p>Stem cell transplants can help people with:</p> <ul> <li>severe blood or <a href="https://kidshealth.org/ws/RadyChildrens/en/teens/immune.html/">immune system</a> illnesses</li> <li>some kinds of <a href="https://kidshealth.org/ws/RadyChildrens/en/teens/cancer.html/">cancer</a></li> <li>immune deficiency</li> <li>autoimmune diseases such as <a href="https://kidshealth.org/ws/RadyChildrens/en/teens/lupus.html/">lupus</a></li> <li>blood disorders (such as thalassemia or <a href="https://kidshealth.org/ws/RadyChildrens/en/teens/sickle-cell-anemia.html/">sickle cell disease</a>)</li> </ul> <h3>Where Do the Stem Cells Come From?</h3> <p>Doctors can get the stem cells from the:</p> <ul> <li>bone marrow (this is also called a <strong>bone marrow transplant</strong>)</li> <li>bloodstream</li> <li>umbilical cord blood after the cord is no longer attached to a newborn baby</li> </ul> <p>A person who provides the stem cells is a <strong>donor</strong>. For some illnesses, people can be their own donor. Their stem cells are taken out, frozen, and transplanted back later. Other times, someone else donates the stem cells.</p> <p>When stem cells come from another person, the stem cells must have similar genetic makeup. Usually, a person's brother or sister is a good match. A parent or even an unrelated person sometimes can be a match.</p> <h3>What Can Happen When a Donor Isn't a Good Match?&nbsp;</h3> <p>If the donor stem cells are not a good match (and sometimes even if they are):</p> <ul class="kh_longline_list"> <li>The body's immune system can attack the donor stem cells. This is called <strong>rejection</strong>.</li> <li>The transplanted cells can attack the body's cells. This is called <strong>graft-versus-host disease</strong>.</li> </ul> <h3>How Are Stem Cell Transplants Done?</h3> <p>Before a stem cell transplant, doctors place a <strong>central line</strong> (or central venous catheter). This type of IV (intravenous) line goes into the skin and into a large vein near the heart. A central line can stay in the body longer than a regular IV. It gives the medical team a way to give medicines and collect blood for testing without doing a lot of needle sticks.</p> <p>Stem cell transplants are done in the hospital. First, the person getting the donated stem cells has high doses of <a href="https://kidshealth.org/ws/RadyChildrens/en/teens/chemo.html/">chemotherapy</a> and/or <a href="https://kidshealth.org/ws/RadyChildrens/en/teens/radiation.html/">radiation</a> to:</p> <ul> <li>kill the unhealthy cells causing the illness</li> <li>weaken their immune system so it doesn't reject the donor stem cells</li> </ul> <p>Then, the person gets the donor stem cells through an intravenous line (IV).</p> <h3>What Happens After the Transplant?</h3> <p>After someone has a stem cell transplant, their body needs time to make new red blood cells, white blood cells, and platelets. During this time, they're at a higher risk for infections, bleeding, and other problems.</p> <p>Most people stay in the hospital for 3–5 weeks after the transplant. Their medical team will:</p> <ul class="kh_longline_list"> <li>Do blood tests to see if the transplanted stem cells are making new blood cells.</li> <li>Give medicines to help prevent rejection and graft-versus-host disease.</li> <li>Give medicines to prevent infections.</li> <li>Give <a href="https://kidshealth.org/ws/RadyChildrens/en/teens/transfusions.html/">transfusions</a> of red blood cells, white blood cells, and platelets.</li> <li>Check that organs (such as the liver and kidneys) are working properly.</li> <li>Treat any problems that happen, such as mouth sores, vomiting, <a href="https://kidshealth.org/ws/RadyChildrens/en/teens/diarrhea.html/">diarrhea</a>, infections, bleeding, rejection, and graft-versus-host disease.</li> <li>Make sure the patient is getting good nutrition.</li> <li>Make sure that all visitors follow infection prevention rules, which include: <ul> <li>No sick visitors.</li> <li>All visitors must <a href="https://kidshealth.org/ws/RadyChildrens/en/teens/handwashing.html/">wash their hands</a> before entering the room.</li> <li>All visitors must wear a mask, gloves, and gown.</li> </ul> </li> </ul> <h3>How Can I Feel Better?</h3> <p>It takes the immune system about a year to recover after a stem cell transplant. Until then, the person can get very sick from infections. Even a mild infection, like a <a href="https://kidshealth.org/ws/RadyChildrens/en/teens/colds.html/">cold</a>, can be serious. To help you avoid infections:</p> <ul class="kh_longline_list"> <li>You, family members, and visitors should wash their hands well and often with antibacterial soap and/or hand sanitizer.</li> <li>Stay away from anyone who is sick.</li> <li>Bathe every day with a mild shampoo and soap.</li> </ul> <p>Follow your medical team's instructions for:</p> <ul> <li>when you can go to school or other public places</li> <li>when you need to wear a mask</li> <li>what foods are OK for you</li> <li>if you can be around pets</li> </ul> <h3>What Else Should I Know?</h3> <p>Most teens who have had a stem cell transplant feel better over time after they leave the hospital. Your health care team knows how tough recovery can be, and how important it is to get emotional support. Your doctor, a hospital social worker, or child life specialist can help you get through this difficult time, so be sure to ask.</p> <h3>When Should I Call the Doctor?</h3> <p>You or your parent should call your doctor right away if you:</p> <ul> <li>have a fever of 100.4&deg;F (38.0&deg;C) or higher</li> <li>have a runny nose, cough, or congestion</li> <li>have vomiting or diarrhea</li> <li>have black bowel movements (poops)</li> <li>have easy bruising or bleeding</li> <li>have <a href="https://kidshealth.org/ws/RadyChildrens/en/teens/hematuria.html/">blood in the pee</a></li> <li>have a <a href="https://kidshealth.org/ws/RadyChildrens/en/teens/headaches.html/">headache</a>, dizziness, or blurred vision</li> <li>cough up blood or have a <a href="https://kidshealth.org/ws/RadyChildrens/en/teens/nosebleeds.html/">nosebleed</a> that won't stop after a few minutes</li> </ul>Trasplantes de células madre Un trasplante de células madre es el procedimiento médico que consiste en introducir células madre sanas en el torrente sanguíneo de una persona para sustituir a sus propias células madre.https://kidshealth.org/ws/RadyChildrens/es/teens/stem-cells-esp.html/20454ea8-b233-441b-a7f5-f3b9c872d35c
Blood Find out about the mysterious, life-sustaining fluid called blood.https://kidshealth.org/ws/RadyChildrens/en/teens/blood.html/4cbf9380-e4e4-445c-92a9-93f01a97516b
Blood TransfusionsAbout 5 million people a year get blood transfusions in the United States. This article explains why people need them and who donates the blood used.https://kidshealth.org/ws/RadyChildrens/en/teens/transfusions.html/e62b4115-02ec-45e0-bab3-ab6097ba1f4d
Cancer BasicsGet the basics on cancer and cancer treatments in this article.https://kidshealth.org/ws/RadyChildrens/en/teens/cancer.html/80768a55-ae26-44d5-82a5-675138383191
Immune SystemThe immune system is made up of special cells, proteins, tissues, and organs that defend people against germs and microorganisms.https://kidshealth.org/ws/RadyChildrens/en/teens/immune.html/45385c22-09f4-4e2e-98d9-8be5155bedc5
LupusLupus is a disease that affects the immune system. Learn how lupus is treated, signs and symptoms, how to support a friend who has it, and more.https://kidshealth.org/ws/RadyChildrens/en/teens/lupus.html/52e90cd8-e8a3-41ef-a32b-0bd6898db239
Sickle Cell DiseaseSickle cell disease is a blood disorder that makes red blood cells change shape and cause health problems. Find out more in this article for teens.https://kidshealth.org/ws/RadyChildrens/en/teens/sickle-cell-anemia.html/1e4b0ffe-7595-4ec6-8104-8b2cef04da60
Words to Know (Cancer Glossary)Check out our cancer glossary for lots of easy-to-read definitions.https://kidshealth.org/ws/RadyChildrens/en/teens/cancer-glossary.html/4ab89876-ef8d-4cf1-a670-d8644dcdf5e8
kh:age-teenThirteenToNineteenkh:age-youngAdultEighteenPluskh:clinicalDesignation-geneticskh:clinicalDesignation-immunologykh:clinicalDesignation-oncologykh:genre-articlekh:primaryClinicalDesignation-oncologyCancer Treatment & Prevention for Teenshttps://kidshealth.org/ws/RadyChildrens/en/teens/cancer-center/treatment/9269d760-2a3e-46a6-bc6f-afd241090a76Cancer & Tumors (for Teens)https://kidshealth.org/ws/RadyChildrens/en/teens/diseases-conditions/cancer/b9326cfc-2178-4cf4-a416-425667cb2c85Medical Tests & Procedures (for Teens)https://kidshealth.org/ws/RadyChildrens/en/teens/diseases-conditions/medical-tests/c583a2a8-0934-4f76-943c-a6b650fe7d41Blood Disorders (for Teens)https://kidshealth.org/ws/RadyChildrens/en/teens/diseases-conditions/blood/99b2f8b3-574e-474d-bee7-b1966603ec66Allergies, Asthma & the Immune System (for Teens)https://kidshealth.org/ws/RadyChildrens/en/teens/diseases-conditions/allergies-immune/58e9cf38-5358-47d8-ba83-03c01c1aa2ca