Hepatoblastomaenparentshttps://kidshealth.org/EN/images/headers/KH_generic_header_05_2.jpgHepatoblastoma is a rare type of cancer that affects the liver but rarely spreads beyond it. Most cases are in children younger than 3. hepatoblastoma, blastoma, liver cancer, liver tumor, tumor in the liver, pediatric cancer, cancer in young kids, metastasize, tumor, tumer, Beckwith-Wiedemann syndrome, chemotherapy, liver transplant, transplants, organ transplants04/20/201811/13/201911/13/2019Howard M. Katzenstein, MD and Allison Aguado, MD10/01/2019957c6476-0139-4721-ab32-d9d75d2265b2https://kidshealth.org/ws/RadyChildrens/en/parents/hepatoblastoma.html/<h3>What Is Hepatoblastoma?</h3> <p>Hepatoblastoma is the most common type of&nbsp;<a href="https://kidshealth.org/ws/RadyChildrens/en/parents/liver-tumors.html/">liver</a> cancer in children. It most often happens in children under age 3.</p> <h3>What Are the Signs &amp; Symptoms of Hepatoblastoma?</h3> <p>A child with hepatoblastoma (heh-puh-toe-blass-TOE-muh) usually will have a painless mass (a large belly that sticks out).</p> <p>Less common symptoms include:</p> <ul> <li>belly pain</li> <li>jaundice (yellow skin or eyes)</li> <li>dark pee</li> <li>back pain</li> <li><a href="https://kidshealth.org/ws/RadyChildrens/en/parents/fever.html/">fever</a></li> <li>itching</li> <li>large veins that can be seen in the skin around the belly</li> <li>loss of appetite</li> <li>weight loss</li> <li>nausea and <a href="https://kidshealth.org/ws/RadyChildrens/en/parents/vomit.html/">vomiting</a></li> </ul> <h3>Who Gets Hepatoblastoma?</h3> <p>Children are more likely to get hepatoblastoma if they:</p> <ul> <li>are <a href="https://kidshealth.org/ws/RadyChildrens/en/parents/preemies.html/">born early</a> with a very low birth weight&nbsp;</li> <li>have a growth disorder called Beckwith-Wiedemann syndrome (which makes the body and internal organs grow too much or get too big)</li> <li>have a <a href="https://kidshealth.org/ws/RadyChildrens/en/parents/about-genetics.html/">genetic</a> condition called familial adenomatous polyposis (which causes growths in the lining of the large intestine)</li> <li>have a problem with a gene (the APC suppressor gene) that normally keeps tumors from growing</li> </ul> <p>Hepatoblastoma is more common in boys than in girls.</p> <h3>How Is Hepatoblastoma Diagnosed?</h3> <p>When a child has hepatoblastoma symptoms, the doctor will do an exam. Tests done may include:</p> <ul> <li>blood tests, including <a href="https://kidshealth.org/ws/RadyChildrens/en/parents/labtest6.html/">liver</a>&nbsp;function tests and an alpha fetoprotein (AFP) test (liver damage and some cancers can raise the level of this protein in the blood)</li> <li>imaging tests: <ul> <li><a href="https://kidshealth.org/ws/RadyChildrens/en/parents/ultrasound-abdomen.html/">ultrasound</a></li> <li><a href="https://kidshealth.org/ws/RadyChildrens/en/parents/xray-abdomen.html/">X-rays</a></li> <li><a href="https://kidshealth.org/ws/RadyChildrens/en/parents/cat-scan-abdomen.html/">CAT scan</a></li> <li><a href="https://kidshealth.org/ws/RadyChildrens/en/parents/mri.html/">MRI</a></li> </ul> </li> <li>a <a href="https://kidshealth.org/ws/RadyChildrens/en/parents/biopsy.html/">biopsy</a>: removing a piece of tumor tissue with the help of ultrasound. This helps the doctor see the best area of the tumor to remove.</li> </ul> <h3>How Is Hepatoblastoma Treated?</h3> <p>Doctors usually treat hepatoblastoma with a combination of surgery and <a href="https://kidshealth.org/ws/RadyChildrens/en/parents/chemotherapy.html/">chemotherapy</a>. If possible, children with cancer should go to a medical center specializing in the treatment of pediatric cancers.</p> <p>Treatment depends on:</p> <ul> <li>the child's age</li> <li>the size of the tumor</li> <li>whether there is one or many tumors in the liver</li> <li>whether the cancer has spread from the liver</li> </ul> <h4>Treatment Options</h4> <p><strong>Surgery</strong> is necessary to cure hepatoblastoma. But because of the size of the tumor, it's not possible in most children at the time they're first diagnosed.</p> <p><strong>Chemotherapy</strong> helps shrink the tumor so that doctors can remove it. Sometimes the tumor is so large that a <a href="https://kidshealth.org/ws/RadyChildrens/en/parents/liver-transplant.html/">liver transplant</a> is needed because the whole liver must be removed to get the entire tumor.</p> <p><a href="https://kidshealth.org/en/parents/radioembolization.html" onclick="window.open(this.href, 'windyWindow', 'width=800,height=600,status=no,scrollbars=yes,toolbar=no,resizable=yes,location=yes'); return false;"><strong>Radioembolization (or Y90)</strong></a> is a type of therapy that delivers high-dose <a href="https://kidshealth.org/ws/RadyChildrens/en/parents/radiation.html/">radiation</a> directly to the liver tumor through the bloodstream. The radiologist inserts a tiny catheter (plastic tube) in the groin and passes it to the artery closest to the tumor. This procedure protects much of the normal liver tissue from the effects of Y90.</p> <p>Y90 can be used as primary therapy in liver tumors that don't respond well to chemotherapy. It's also used when hepatoblastoma tumors come back or don't shrink enough for surgery.</p> <p><strong style="font-size: 1em;">Transarterial chemoembolization (TACE)</strong><span style="font-size: 1em;">, which sends chemotherapy particles directly to the tumor.</span></p> <p><strong>Tumor ablation</strong>, which is when doctors destroy tumors by using small needles to heat or cool them.</p> <h3>Who Treats Hepatoblastoma?</h3> <p>Hepatoblastoma is treated by a health care team, including specialists in:</p> <ul> <li>oncology (cancer)/hematology (blood diseases)</li> <li>surgery</li> <li><a href="https://kidshealth.org/ws/RadyChildrens/en/parents/intvnl-radiology.html/">interventional radiology</a>&nbsp;(image-guided minimally invasive procedures)</li> <li>gastroenterology (digestive tract) and hepatology (liver)</li> <li>pathology (diagnosing diseases by examining body tissues, fluids, and organs )</li> <li>genetics (genetic counseling and <a href="https://kidshealth.org/ws/RadyChildrens/en/parents/genetics.html/">testing</a>)</li> <li>radiology (medical imaging)</li> <li>nutrition</li> </ul> <h3>Looking Ahead</h3> <p>If a surgeon removes the cancer completely, a child's outlook is generally good. After treatment, the doctor will do a checkup every year to see if the cancer has come back, but this doesn't happen in most cases. The doctor also will treat any long-term or <a href="https://kidshealth.org/ws/RadyChildrens/en/parents/late-effects.html/">late side effects</a> from the treatment.</p> <p>Having a child being treated for cancer can feel overwhelming for any family. But you're not alone. To find support, talk to your child's doctor or a hospital social worker. Many resources are available to help you get through this difficult time.</p> <p>You also can find information and support online at:</p> <ul> <li><a href="https://www.cancer.gov/types/liver/patient/child-liver-treatment-pdq">National Cancer Institute</a></li> <li><a href="https://www.acco.org/hepatoblastoma/">American Childhood Cancer Organization</a></li> <li><a href="https://liverfoundation.org/">American Liver Foundation</a></li> </ul>HepatoblastomaUn hepatoblastoma es el tipo de cáncer de hígado más frecuente en los niños. Afecta más a menudo a niños menores de 3 años de edad. https://kidshealth.org/ws/RadyChildrens/es/parents/hepatoblastoma-esp.html/694357b2-61ca-4615-8e68-a34b33fde69b
ChemotherapyChemotherapy (chemo) is treatment with medicines that stop the growth of cancer cells.https://kidshealth.org/ws/RadyChildrens/en/parents/chemotherapy.html/54f93018-4955-4463-b067-5621e285210f
Childhood CancerDifferent kinds of childhood cancer have different signs, symptoms, treatments, and outcomes. But today, most kids with cancer get better.https://kidshealth.org/ws/RadyChildrens/en/parents/cancer.html/fb37fd75-d961-43c2-b963-ef6f60486038
Late Effects of Cancer and Cancer TreatmentLong-term side effects, or late effects, happen to many cancer survivors. With early diagnosis and proper follow-up care, most late effects can be treated or cured.https://kidshealth.org/ws/RadyChildrens/en/parents/late-effects.html/4f0ec7e2-6a0d-4c67-b4e7-f6e15de2816d
Liver TumorsTumors happen when cells form a mass or growth. Liver tumors can be benign (not cancerous) or malignant (cancerous).https://kidshealth.org/ws/RadyChildrens/en/parents/liver-tumors.html/ef61411a-f830-4846-a20f-56ac5e49076b
Proton Therapy for CancerProton therapy is an advanced type of radiation therapy. It's an effective treatment for many childhood cancers.https://kidshealth.org/ws/RadyChildrens/en/parents/proton-therapy.html/acda9533-9f01-40dc-99ef-abc2938bca03
Radioembolization (TARE-Y90) for Liver TumorsRadioembolization is a procedure used to treat some kinds of liver tumors. A radioactive material works on the tumor, not the healthy tissue around it.https://kidshealth.org/ws/RadyChildrens/en/parents/radioembolization.html/8ff3de84-a008-42c9-bd79-cb927e15da97
When Your Child Needs a Liver TransplantIf your child needs a liver transplant, you're probably feeling lots of emotions. Fortunately, most kids who have liver transplants go on to live normal, healthy lives.https://kidshealth.org/ws/RadyChildrens/en/parents/liver-transplant.html/74340ca2-6b5b-4b7e-85f5-4db45aee1e9a
Wilms TumorWilms tumor is a cancer of the kidneys that usually affects newborns and the very young. Fortunately, most kids with Wilms tumor survive and go on to live normal, healthy lives.https://kidshealth.org/ws/RadyChildrens/en/parents/wilms.html/04155d1b-c25f-435e-b430-877088037392
Words to Know (Cancer Glossary)Check out our cancer glossary for lots of easy-to-read definitions.https://kidshealth.org/ws/RadyChildrens/en/parents/cancer-glossary.html/b23569e7-7ecf-4e78-8aad-108e0ab04842
kh:age-allAgesOrAgeAgnostickh:clinicalDesignation-oncologykh:genre-articlekh:primaryClinicalDesignation-oncologyCancer Basicshttps://kidshealth.org/ws/RadyChildrens/en/parents/cancer-center/cancer-basics/9ea0efb4-12d0-4d11-8b46-923deeb7b806Cancer & Tumorshttps://kidshealth.org/ws/RadyChildrens/en/parents/medical/cancer/088d4c52-cd61-4cca-af46-82de410d892a