A to Z: Tuberous Sclerosisenparentshttps://kidshealth.org/EN/images/headers/P-KH-AZ-Dictionary-enHD.jpgLearn about this genetic disorder that causes noncancerous tumors to grow in many parts of the body.Tuberous sclerosis, TS, tuberous sclerosis complex, TSC, Bourneville disease, epiloia, tumors, benign tumors, neurocutaneous syndrome, brain, nervous system, heart, kidneys, lungs, skin, skin lesions, genetic disorders, seizures, developmental delays, behavioral problems, eyes06/08/201504/11/201909/02/20198edcae4f-a2df-4b20-8b9d-de385da2eecfhttps://kidshealth.org/ws/RadyChildrens/en/parents/az-tuberous.html/<p><em>May also be called: TS, Tuberous Sclerosis Complex, TSC, Bourneville Disease, Epiloia</em></p> <p>Tuberous sclerosis (TOO-buh-rus skluh-ROH-sus) is a genetic disorder that can cause noncancerous tumors to form in many parts of the body. "Genetic disorder" means it's the result of a change in genes that's either inherited (passed on from parent to child)&nbsp;or happens during development in the womb.</p> <h3>More to Know</h3> <p>Tuberous sclerosis, or TS, is a <a href="https://kidshealth.org/ws/RadyChildrens/en/parents/neurocutaneous.html/">neurocutaneous syndrome</a> &mdash; a disorder that can cause tumors to form in various parts of the body. (A<span style="line-height: 16.8px;">&nbsp;tumor is a lump or mass that can form when c</span><span style="font-size: 1em; line-height: 1.4em;">ells grow abnormally or out of control.) With TS, tumors can develop in the brain, eyes, kidneys, heart, lungs, bones, or skin. TS is caused by mutations in </span><a href="https://kidshealth.org/ws/RadyChildrens/en/parents/about-genetics.html/" style="font-size: 1em; line-height: 1.4em;">genes</a><span style="font-size: 1em; line-height: 1.4em;"> that help control cell growth. Children inherit the mutations from their parents, and each child of a parent with TS has a 50% chance of having it. TS is rare, happening in about 1 in 6,000 births.</span></p> <p>TS symptoms can be different depending on the location of the tumors. TS is often first recognized when a child has <a href="https://kidshealth.org/ws/RadyChildrens/en/parents/seizure.html/">seizures</a> or shows developmental delays. Other common symptoms include behavior problems and problems with the kidneys, heart, lungs, and eyes. TS can also cause skin abnormalities, such as patches of light-colored or thickened skin.</p> <p>Doctors prescribe medicine to control seizures caused by TS. Children may also need surgery for heart or kidney tumors, medicine to manage high blood pressure caused by kidney disease, and skin creams and ointments to treat skin problems. Treatment for children with TS who have developmental delays usually also includes physical therapy, <a href="https://kidshealth.org/ws/RadyChildrens/en/parents/occupational-therapy.html/">occupational therapy</a>, and <a href="https://kidshealth.org/ws/RadyChildrens/en/parents/speech-therapy.html/">speech therapy</a>.</p> <h3>Keep in Mind</h3> <p>Many children with TS have mild symptoms or never develop symptoms and have a normal life expectancy. Others can be severely disabled and have a shortened life span. There is no cure for TS, but researchers are looking at new medicine that may help delay tumor growth and shrink tumors in people with TS.</p> <p><em>All A to Z dictionary entries are regularly reviewed by KidsHealth medical experts.</em></p>
All About GeneticsRead the basics about genetics, including how certain illnesses, or increased risks for certain illnesses, pass from generation to generation.https://kidshealth.org/ws/RadyChildrens/en/parents/about-genetics.html/0a35cfc5-5d12-46d2-b0a9-ffae83cace5c
Gene Therapy and ChildrenGene therapy carries the promise of cures for many diseases and for types of medical treatment most of us would not have thought possible.https://kidshealth.org/ws/RadyChildrens/en/parents/gene-therapy.html/a62423ca-6e1e-4a80-b100-ddeec746b2b5
Genetic TestingAdvances in genetic testing help doctors diagnose and treat certain illnesses. The type of test done depends on which condition a doctor checks for.https://kidshealth.org/ws/RadyChildrens/en/parents/genetics.html/cbe49a95-6833-41f4-881a-c26287c4a33c
Kidney Diseases in ChildhoodThe kidneys play a critical role in health. When something goes wrong, it could indicate a kidney disease. What are kidney diseases, and how can they be treated?https://kidshealth.org/ws/RadyChildrens/en/parents/kidney-diseases-childhood.html/ce75e066-a9e8-498f-97e8-6459154b9748
Neurocutaneous SyndromesNeurocutaneous syndromes are genetic disorders that lead to tumor growth in various parts of the body. Learn how to maximize the quality of life for children with these diseases.https://kidshealth.org/ws/RadyChildrens/en/parents/neurocutaneous.html/7e9e3b3a-59da-4998-8655-57927110240f
SeizuresSeizures are caused by a sudden surge of electrical activity in the brain. Find out what you need to know about seizures and what to do if your child has one.https://kidshealth.org/ws/RadyChildrens/en/parents/seizure.html/17184860-dea1-4cd4-95ba-3cf34539cd44
kh:age-allAgesOrAgeAgnostickh:clinicalDesignation-geneticskh:genre-articlekh:primaryClinicalDesignation-neurologyThttps://kidshealth.org/ws/RadyChildrens/en/parents/dictionary/t/43c185a2-6bf4-4283-b27b-c17577050c89