A to Z: Osteogenesis Imperfectaenparentshttps://kidshealth.org/EN/images/headers/P-khAZDictionary-enHD-AR1.jpgLearn more about congenital disorders and bone deformities.osteogenesis imperfecta, OI, bones, brittle bone disease, collagen, fractures, broken bones, skeleton, bone deformities, genetic defects, CD1Brittle Bone Disease11/26/201208/11/201609/02/2019f1bc6216-8a3f-49c9-a2e1-fd7e372510f3https://kidshealth.org/ws/RadyChildrens/en/parents/az-oi.html/<h1>A to Z: Osteogenesis Imperfecta</h1> <p><em>May also be called: Brittle Bone Disease; OI</em></p> <p>Osteogenesis imperfecta (os-tee-oh-JEN-uh-sis im-pur-FEK-tuh) is an inherited <a href="https://kidshealth.org/ws/RadyChildrens/en/parents/about-genetics.html/">genetic</a> disorder that weakens the <a href="https://kidshealth.org/ws/RadyChildrens/en/parents/bones-muscles-joints.html/">bones</a> and makes them break, or fracture, easily.</p> <h3>More to Know</h3> <p>Collagen is an important building block of bones. Because of a defect in the gene that produces collagen, people with OI either don't have enough collagen in their bones or have collagen that doesn't work properly. This causes their bones to be weaker and more brittle than normal bones. It can also lead to bone deformities.</p> <p>The severity of osteogenesis imperfecta can vary. Some people won't know they have it until they fall and break a bone. For them, the only symptom of OI might be an occasional fracture. In rare cases, children are born with <a href="https://kidshealth.org/ws/RadyChildrens/en/parents/b-bone.html/">broken bones</a> that require surgery. Some people will most likely need treatment to maintain bone strength for the rest of their lives.</p> <h3>Keep in Mind</h3> <p>There is no cure for osteogenesis imperfecta, but people with OI can minimize their risk of broken bones by avoiding activities that put them at risk of a fall or collision. Low-impact exercise to increase muscle strength and mobility and certain medications can help increase bone strength to further reduce the risk of fractures.</p> <p><em>All A to Z dictionary entries are regularly reviewed by KidsHealth medical experts.</em></p>
Bones, Muscles, and JointsOur bones, muscles, and joints form our musculoskeletal system and enable us to do everyday physical activities.https://kidshealth.org/ws/RadyChildrens/en/teens/bones-muscles-joints.html/d55a922b-e87a-49e0-82ae-0c5a0773cee9
Broken BonesBones are tough stuff - but even tough stuff can break. Find out what happens when a bone fractures.https://kidshealth.org/ws/RadyChildrens/en/teens/broken-bones.html/476538a9-5cb5-422b-89b1-8a93f30a8fce
Your BonesWhere would you be without your bones? Learn more about the skeletal system in this article for kids.https://kidshealth.org/ws/RadyChildrens/en/kids/bones.html/ba77b482-c6eb-47da-90a4-3cb148f38f4d
kh:age-allAgesOrAgeAgnostickh:clinicalDesignation-geneticskh:genre-dictionarykh:primaryClinicalDesignation-orthopedicsNonSportsMedOhttps://kidshealth.org/ws/RadyChildrens/en/parents/dictionary/o/b2d013ce-22c0-46dc-86ab-548a92a2de71Orthopedics A to Zhttps://kidshealth.org/ws/RadyChildrens/en/parents/dictionary/az-ortho/9fdd6bbc-254a-4dff-be33-c4c6c66c3f6e