A to Z: Li-Fraumeni Syndromeenparentshttps://kidshealth.org/EN/images/headers/P-KH-AZ-Dictionary-enHD.jpgThis genetic condition makes a person more likely to get cancer during his or her lifetime. Learn more here.Li-Fraumeni syndrome, LFS, cancer, tumors, genetic disorders, genes, leukemia, breast cancer, brain tumors, osteosarcoma, soft-tissue tumors, bone tumors, soft-tissue sarcoma, gene therapy, chemotherapy, genetic defects, TP53, cell growth, tumor suppressor, adrenal gland, adrenocortical tumors06/08/201504/05/201909/02/2019f4dfc7a9-39a0-472b-add5-7dc212e5967fhttps://kidshealth.org/ws/RadyChildrens/en/parents/az-li-fraumeni.html/<p><em>May also be called: LFS</em></p> <p>Li-Fraumeni (LEE frow-MEE-nee) syndrome, or LFS, is a rare genetic disorder that makes a child likely to develop cancer at some point in his or her life.</p> <h3>More to Know</h3> <p>Li-Fraumeni syndrome means a person has a defect in a gene called TP53. TP53 helps control the growth of cells. If the gene isn't working correctly, cells can grow out of control and tumors may form. This can lead to several types of cancer, including breast cancer, <a href="https://kidshealth.org/ws/RadyChildrens/en/parents/cancer-leukemia.html/">leukemia</a>, <a href="https://kidshealth.org/ws/RadyChildrens/en/parents/brn-tumors.html/">brain tumors</a>, <a href="https://kidshealth.org/ws/RadyChildrens/en/parents/rms.html/">soft-tissue tumors</a>, and bone tumors (<a href="https://kidshealth.org/ws/RadyChildrens/en/parents/cancer-osteosarcoma.html/">osteosarcomas</a>). Cancers caused by&nbsp;<span style="line-height: 16.8px;">Li-Fraumeni syndrome</span>&nbsp;often&nbsp;first develop in children or young adults, but they can happen to people of any age.</p> <p>Li-Fraumeni syndrome is usually inherited from a parent who also has the genetic defect, but in rare cases the defect can be caused by a random mutation.</p> <p><span style="line-height: 16.8px;">Li-Fraumeni syndrome&nbsp;</span>is diagnosed through <a href="https://kidshealth.org/ws/RadyChildrens/en/parents/genetics.html/">genetic testing</a>. Symptoms and treatment both depend on which type of cancer develops.</p> <h3>Keep in Mind</h3> <p>There is currently no cure for&nbsp;<span style="line-height: 16.8px;">Li-Fraumeni syndrome</span>. Early&nbsp;diagnosis can help doctors be ready to treat any tumors or cancers that develop. The earlier treatment is started, the more effective it is, increasing the chances of a good long-term outcome.</p> <p><em>All A to Z dictionary entries are regularly reviewed by KidsHealth medical experts.</em></p>
Acute Lymphoblastic Leukemia (ALL)Acute lymphoblastic leukemia (ALL) is the most common type of childhood cancer. Because it develops and gets worse quickly, prompt treatment is very important. With treatment, most kids are cured.https://kidshealth.org/ws/RadyChildrens/en/parents/all.html/70e490be-1dce-4795-821e-c0ba28838828
Brain TumorsBrain tumors are the second most common group of childhood cancers. Treatment requires a very specialized plan involving a team of medical specialists.https://kidshealth.org/ws/RadyChildrens/en/parents/brn-tumors.html/ff2bd11c-a3d8-4bb3-bb58-edd97dd13a31
Brain and Nervous System CancersThese cancers are the most common type of cancer in children. When discovered early, they often can be cured.https://kidshealth.org/ws/RadyChildrens/en/parents/brain-tumors.html/527c1203-9898-45b5-8dba-3de70f76df5d
Genetic TestingAdvances in genetic testing help doctors diagnose and treat certain illnesses. The type of test done depends on which condition a doctor checks for.https://kidshealth.org/ws/RadyChildrens/en/parents/genetics.html/cbe49a95-6833-41f4-881a-c26287c4a33c
LeukemiaLeukemia refers to cancers of the white blood cells. With the proper treatment, the outlook for kids with leukemia is quite good.https://kidshealth.org/ws/RadyChildrens/en/parents/cancer-leukemia.html/d78fde51-319d-4c82-9476-e1e16f31c187
Liver TumorsTumors happen when cells form a mass or growth. Liver tumors can be benign (not cancerous) or malignant (cancerous).https://kidshealth.org/ws/RadyChildrens/en/parents/liver-tumors.html/ef61411a-f830-4846-a20f-56ac5e49076b
LymphomaLymphoma is cancer that begins in the body's lymphatic tissue. It's a common type of cancer in children, but most recover from it.https://kidshealth.org/ws/RadyChildrens/en/parents/cancer-lymphoma.html/0ad821a9-0139-4995-81e6-6c365a632f00
NeuroblastomaLearn about neuroblastoma, a rare type of childhood cancer that develops in infants and young children.https://kidshealth.org/ws/RadyChildrens/en/parents/neuroblastoma.html/bee4b21c-7e49-4a5c-ae2c-5aeafafc4187
OsteosarcomaOsteosarcoma is the most common type of bone cancer. Boys are more likely to have osteosarcoma than girls, and most cases of osteosarcoma involve the knee.https://kidshealth.org/ws/RadyChildrens/en/parents/cancer-osteosarcoma.html/2a1588a0-1908-44bb-9bd8-db63c33806ce
RetinoblastomaRetinoblastoma is a childhood cancer that affects the retina, the area of the eye responsible for sensing light and sending nerve signals to the brain.https://kidshealth.org/ws/RadyChildrens/en/parents/retinoblastoma.html/4a9d3ca6-8bf9-4d09-9bc7-8a28f61cd859
Rhabdomyosarcoma (RMS)Rhabdomyosarcoma is a cancerous tumor that shows up in the body's soft tissues. With early diagnosis and timely treatment, most kids make a full recovery.https://kidshealth.org/ws/RadyChildrens/en/parents/rms.html/6a0ef07e-132c-48fb-8368-3081bfc72c45