A to Z: Graft Versus Host Diseaseenparentshttps://kidshealth.org/EN/images/headers/P-khAZDictionary-enHD-AR1.jpgWhen a person receives a stem cell transplant, this treatable complication can make it tougher for the immune system to heal.Graft versus host disease, GVHD, acute GVHD, chronic GVHD, stem cell transplant, bone marrow transplant, cancer, blood disorders, immune system diseases, bone marrow syndromes, bone marrow, white blood cells, liver, lungs, skin rash, organ donor, immune system, suppression therapy06/30/201403/18/201909/02/20199ebb3ea5-82d4-4c39-8aa2-518f4344d2a0https://kidshealth.org/ws/RadyChildrens/en/parents/az-graft-versus-host-disease.html/<p><a href="https://kidshealth.org/ws/RadyChildrens/en/parents/dictionary/"><img class="right" title="Parents image" src="https://kidshealth.org/EN/images/buttons/P-atoZDictionary-enBT.jpg" alt="A to Z Dictionary 500 Go" name="5093-P_ATOZDICTIONARY2_ENBT.JPG" /></a></p> <p><strong>May also be called: GVHD; Acute GVHD; Chronic GVHD</strong></p> <p>Graft versus host disease, or GVHD, is a complication of <a href="https://kidshealth.org/ws/RadyChildrens/en/parents/stem-cells.html/">stem cell transplants</a> in which white blood cells from the transplanted tissue (graft) attack the transplant recipient's body (host).</p> <h3>More to Know</h3> <p>Stem cell transplants (sometimes called bone marrow transplants) are done to treat a variety of diseases, including many types of cancers, blood disorders, <a href="https://kidshealth.org/ws/RadyChildrens/en/parents/immune.html/">immune system</a> diseases, and bone marrow syndromes.</p> <p>In a stem cell transplant, a donor gives cells (also called tissue) to someone who is sick (the transplant recipient). Sometimes, after a stem cell transplant, the white blood cells in the transplanted tissue see the transplant recipient as "foreign" and attack healthy tissue.</p> <p>Symptoms of&nbsp;GVHD can range from abdominal pain, nausea, vomiting, and dry mouth to&nbsp;muscle weakness, fatigue, and skin rashes.</p> <p>GVHD can be acute (usually happening within the first 3 months after a transplant) or chronic (happening later and possibly lasting&nbsp;for the rest of the recipient's life). In severe cases, GVHD can damage the liver, lungs, or other organs and can become life threatening.</p> <p>The closer the match between the transplant recipient and the tissue donor, the less risk there is of GVHD. That's why doctors try to match people who need stem cell transplants with identical twins or other close relatives.</p> <p>People who receive transplants usually take drugs to suppress the body's immune system. This can help prevent GVHD or reduce the severity of any symptoms.</p> <h3>Keep in Mind</h3> <p>Many cases of GVHD are treated successfully. But that doesn't guarantee that the transplanted tissue will cure the original disease. The long-term outlook for someone with GVHD depends on how severe that disease is. Transplant success is&nbsp;more likely when the received tissue is donated by someone whose cells are a close match.</p> <p><em>All A to Z dictionary entries are regularly reviewed by KidsHealth medical experts.</em></p>
Aspiration and Biopsy: Bone MarrowA bone marrow aspiration and biopsy are performed to examine bone marrow, the spongy liquid part of the bone where blood cells are made.https://kidshealth.org/ws/RadyChildrens/en/parents/aspiration.html/5925b589-4487-4975-85f6-850dc8c31e07
Cancer CenterFrom treatments and prevention to coping with the emotional aspects of cancer, the Cancer Center provides comprehensive information that parents need.https://kidshealth.org/ws/RadyChildrens/en/parents/center/cancer-center.html/92fcdf56-6935-42ac-a953-9eaf5f96fe2f
Cord Blood BankingShould you bank your newborn's cord blood? This article can help you decide.https://kidshealth.org/ws/RadyChildrens/en/parents/cord-blood.html/e0639a20-b8ba-4892-b03b-58f1c2d98efb
Severe Combined ImmunodeficiencySevere combined immunodeficiency (SCID) is an immune deficiency that can be successfully treated if it's found early.https://kidshealth.org/ws/RadyChildrens/en/parents/severe-immunodeficiency.html/abe0da22-f4d2-453c-9acb-39b9ed61f021
Stem Cell TransplantsStem cells help rebuild a weakened immune system. Stem cell transplants are effective treatments for a wide range of diseases, including cancer.https://kidshealth.org/ws/RadyChildrens/en/parents/stem-cells.html/d98ca062-7d31-45ea-ae16-8fc40d54aea7
kh:age-allAgesOrAgeAgnostickh:clinicalDesignation-immunologykh:genre-dictionarykh:primaryClinicalDesignation-oncologyOncology (Cancer) A to Zhttps://kidshealth.org/ws/RadyChildrens/en/parents/dictionary/az-onco/a7735711-c7f1-46e3-a571-50ca4db487ccGhttps://kidshealth.org/ws/RadyChildrens/en/parents/dictionary/g/913c41ca-555f-4809-b0b6-47479a8abc65https://kidshealth.org/EN/images/buttons/P-atoZDictionary-enBT.jpg