A to Z: Granulomatosis with Polyangiitis (GPA)enparentshttps://kidshealth.org/EN/images/headers/P-khAZDictionary-enHD-AR1.jpgLearn about granulomatosis with polyangiitis (GPA), an uncommon autoimmune disorder that causes inflammation of the blood vessels.Granulomatosis With Polyangiitis (GPA), granulomatosis, granulomatosis with polyangiitis, GPA, WG, blood vessels, inflammation, restricted blood flow, kidney failure, organ damage, cold symptoms03/27/201304/01/201909/02/20191655a936-3b8d-4806-bda9-e7f4074cf5achttps://kidshealth.org/ws/RadyChildrens/en/parents/az-gpa.html/<p>Granulomatosis with polyangiitis (GPA) is an uncommon autoimmune disorder that makes <a href="https://kidshealth.org/ws/RadyChildrens/en/parents/blood.html/">blood</a> vessels become inflamed.</p> <h3>More to Know</h3> <p>Most often diagnosed in middle-aged adults, granulomatosis with polyangiitis is rarely seen in children. Its cause is unknown.</p> <p>Some people with GPA may develop small nodules, especially around blood vessels, called granulomas. Blood vessel inflammation affects blood flow, which can damage organs.</p> <p>Symptoms usually affect the <a href="https://kidshealth.org/ws/RadyChildrens/en/parents/lungs.html/">respiratory system</a> first (sinuses, throat, and lungs). The condition progresses quickly, though, and can be life-threatening if it affects the <a href="https://kidshealth.org/ws/RadyChildrens/en/parents/kidneys-urinary.html/">kidneys</a>. Many people with GPA also develop eye problems.</p> <p>People with GPA may have:</p> <ul> <li>a constant runny nose</li> <li>ear infections</li> <li><a href="https://kidshealth.org/ws/RadyChildrens/en/parents/sinusitis.html/">sinusitis</a></li> <li>nosebleeds</li> <li>a cough</li> <li>joint pain</li> <li>shortness of breath</li> <li>skin sores</li> <li>fatigue (tiredness)</li> <li>loss of appetite</li> <li><a href="https://kidshealth.org/ws/RadyChildrens/en/parents/fever.html/">fever</a></li> </ul> <p>Coughing up blood or <a href="https://kidshealth.org/ws/RadyChildrens/en/parents/hematuria.html/">blood in the urine</a> also can be signs of GPA.</p> <h3>Keep in Mind</h3> <p>Doctors treat granulomatosis with polyangiitis with a variety of medicines, such as steroids and others that suppress the <a href="https://kidshealth.org/ws/RadyChildrens/en/parents/immune.html/">immune system</a>. The medicines are effective, but the disease can come back, and treatment can have side effects. So patients with GPA will be closely watched by their doctor.</p> <p><em>All A to Z dictionary entries are regularly reviewed by KidsHealth medical experts.</em></p>
A to Z: SarcoidosisLearn about abnormal immune system responses and disorders that can affect the lungs, lymph system, and other organs.https://kidshealth.org/ws/RadyChildrens/en/parents/az-sarcoidosis.html/373dcab1-132b-4f64-b3dd-93e057dd391a
Immune SystemThe immune system, composed of special cells, proteins, tissues, and organs that protect against germs and microorganisms, is the body's defense against disease.https://kidshealth.org/ws/RadyChildrens/en/parents/immune.html/d5495b69-ecfe-4b16-a87f-a9f5664e71d6
kh:age-allAgesOrAgeAgnostickh:clinicalDesignation-immunologykh:genre-dictionarykh:primaryClinicalDesignation-immunologyGhttps://kidshealth.org/ws/RadyChildrens/en/parents/dictionary/g/913c41ca-555f-4809-b0b6-47479a8abc65