It's often called the "stress hormone" because cortisol
gives our bodies the energy to fight stress, such as a fever,
illness, injury, or a dangerous situation (the "fight-or-flight" response).
It signals the body to speed up the
of stored sugar, fat, and protein, turning these into energy.
Doctors use manmade cortisol, or hydrocortisone, to treat asthma,
allergies, and inflammation.
What Are the Signs & Symptoms of Cushing Syndrome?
Symptoms of Cushing syndrome might take months to develop. They can include:
thicker, more noticeable facial hair in girls (hirsutism)
What Causes Cushing Syndrome?
Cushing syndrome can happen if someone takes large amounts of corticosteroid drugs,
such as prednisone. This is known as exogenous (ek-SAH-jeh-nis) Cushing
Someone might take oral corticosteroids (pills taken by mouth) to:
treat an inflammatory disease such as rheumatoid arthritis, lupus,
prevent the body from rejecting a transplanted organ
Less often, a corticosteroid applied to the skin (for instance, to treat eczema)
or inhaled (to treat asthma) can lead to Cushing syndrome if used in very high doses.
Cushing syndrome also can happen if the body makes too much cortisol. This is known
as endogenous (en-DAH-jeh-nis) Cushing syndrome.
In children, Cushing syndrome usually happens because of:
a problem in the adrenal gland that makes it produce too much cortisol
a problem in the
(most of these are not cancerous)
How Is Cushing Syndrome Diagnosed?
A doctor may suspect Cushing syndrome if a person has the telltale signs, such
as a rounded face, a pad of fatty tissue between the shoulders, thin skin with bruises
and stretch marks, and poor growth.
In children, doctors might suspect Cushing syndrome when a child is gaining weight
but not growing as expected.
The doctor will do a physical exam and ask if the child has been taking a corticosteroid
medicine for a long time. In kids not taking a corticosteroid medicine, doctors might
order tests. These can include:
24-hour urinary free-cortisol test: a urine
test that collects urine (pee) for 24 hours to measure hormone levels
a diurnal cortisol test: measuring cortisol in a blood or saliva
a low-dose dexamethasone suppression test: doing a blood test
to measure cortisol after the child takes a glucocorticoid
a CRH stimulation test: doing repeated blood draws over several
hours to measure cortisol levels after the child gets a shot of corticotropin-releasing
How Is Cushing Syndrome Treated?
A pediatric endocrinologist
will oversee the care of a child with Cushing syndrome. Depending on what's causing
it, treatment for Cushing syndrome might involve:
surgery to remove tumors or growths on the adrenal or pituitary glands
changing how much or how often a child takes a corticosteroid medicine
taking drugs that block the production of hormones
What Else Should I Know?
Children with Cushing syndrome will have follow-up visits with their pediatric
endocrinologist every 3–6 months. The doctor will check hormone levels, adjust medicines
as needed, and see if symptoms have improved. To do this, the doctor might:
order blood tests and urine tests
see if the child is reaching the expected height and weight goals