Granulomatosis with polyangiitis (GPA) is an uncommon
disorder that makes blood
vessels become inflamed.
More to Know
Most often diagnosed in middle-aged adults, granulomatosis with polyangiitis is
rarely seen in children. Its cause is unknown.
Some people with GPA may develop small nodules, especially around blood vessels,
called granulomas. Blood vessel
affects blood flow, which can damage organs.
Symptoms usually affect the respiratory
system first (sinuses, throat, and lungs). The condition progresses quickly, though,
and can be life-threatening if it affects the kidneys.
Many people with GPA also develop eye problems.
Doctors treat granulomatosis with polyangiitis with a variety of medicines, such
as steroids and others that suppress the immune
system. The medicines are effective, but the disease can come back, and treatment
can have side effects. So patients with GPA will be closely watched by their doctor.
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