Whether you're stomping through the showers in your bare feet after gym class or
touching the bathroom doorknob, you're being exposed to germs.
Fortunately for most of us, the immune system is constantly on call to do battle with
bugs that could put us out of commission.
What the Immune System Does
The immune (pronounced: ih-MYOON) system, which is made up of special cells, proteins,
tissues, and organs, defends people against germs and microorganisms every day. In
most cases, the immune system does a great job of keeping people healthy and preventing
infections. But sometimes, problems with the immune system can lead to illness and
The immune system is the body's defense against infectious organisms and other
invaders. Through a series of steps called the immune response, the
immune system attacks organisms and substances that invade our systems and cause disease.
The immune system is made up of a network of cells, tissues, and organs that work
together to protect the body.
The cells that are part of this defense system include white blood cells, also
called leukocytes (pronounced: LOO-kuh-sytes). They come in two basic
types (more on these below), which combine to seek out and destroy the organisms or
substances that cause disease.
Leukocytes are produced and stored in many locations throughout the body, including
the thymus, spleen, and bone marrow. For this reason, they are called the lymphoid
(pronounced: LIM-foyd) organs. There are also clumps of lymphoid tissue throughout
the body, primarily in the form of lymph nodes, that house the leukocytes.
The leukocytes circulate through the body between the organs and nodes by means
of the lymphatic (pronounced: lim-FAT-ik) vessels.
(You can think of the lymphatic vessels as a type of highway between the rest stops
that are the lymphoid organs and lymph nodes.) Leukocytes can also circulate through
the blood vessels. In this way, the immune system works in a coordinated manner to
monitor the body for germs or substances that might cause problems.
There are two basic types of leukocytes:
The phagocytes (pronounced: FAH-guh-sytes) are cells that chew
up invading organisms.
The lymphocytes (pronounced: LIM-fuh-sytes) are cells that allow
the body to remember and recognize previous invaders and help the body destroy them.
A number of different cells are considered phagocytes. The most common type is
the neutrophil (pronounced: NOO-truh-fil), which primarily fights
bacteria. So when doctors are worried about a bacterial infection, sometimes they
order a blood test to see if a patient has an increased number of neutrophils triggered
by the infection. Other types of phagocytes have their own jobs to make sure that
the body responds appropriately to a specific type of invader.
There are two kinds of lymphocytes: the B lymphocytes and the
T lymphocytes. Lymphocytes start out in the bone marrow and either
stay and mature there to become B cells or leave for the thymus gland, where they
mature to become T cells.
B lymphocytes and T lymphocytes have separate jobs to do: B lymphocytes are like
the body's military intelligence system, seeking out their targets and sending defenses
to lock onto them. T cells are like the soldiers, destroying the invaders that the
intelligence system has identified. Here's how it works.
A foreign substance that invades the body is called an antigen
(pronounced: AN-tih-jun). When an antigen is detected, several types of cells work
together to recognize and respond to it. These cells trigger the B lymphocytes to
produce antibodies (pronounced: AN-tye-bah-deez). Antibodies are
specialized proteins that lock onto specific antigens. Antibodies and antigens fit
together like a key and a lock.
Once the B lymphocytes recognize specific antigens, they develop a memory for the
antigen and will produce antibodies the next time the antigen enters a person's body.
That's why if someone gets sick with a certain disease, like chickenpox, that person
typically doesn't get sick from it again.
This is also why we use immunizations to prevent certain diseases. The immunization
introduces the body to the antigen in a way that doesn't make a person sick, but it
does allow the body to produce antibodies that will then protect that person from
future attack by the germ or substance that produces that particular disease.
Although antibodies can recognize an antigen and lock onto it, they are not capable
of destroying it without help. That is the job of the T cells. The T cells are part
of the system that destroys antigens that have been tagged by antibodies or cells
that have been infected or somehow changed. (There are actually T cells that are called
"killer cells.") T cells are also involved in helping signal other cells (like phagocytes)
to do their jobs.
Antibodies can also neutralize toxins (poisonous or damaging substances) produced
by different organisms. Lastly, antibodies can activate a group of proteins called
complement that are also part of the immune system. Complement assists
in killing bacteria, viruses, or infected cells.
All of these specialized cells and parts of the immune system offer the body protection
against disease. This protection is called immunity.
Humans have three types of immunity — innate, adaptive, and passive:
Everyone is born with innate (or natural) immunity, a type of general protection
that humans have. Many of the germs that affect other species don't harm us. For example,
the viruses that cause leukemia in cats or distemper in dogs don't affect humans.
Innate immunity works both ways because some viruses that make humans ill —
such as the virus that causes HIV/AIDS — don't make cats or dogs sick either.
Innate immunity also includes the external barriers of the body, like the skin
and mucous membranes (like those that line the nose, throat, and gastrointestinal
tract), which are our first line of defense in preventing diseases from entering the
body. If this outer defensive wall is broken (like if you get a cut), the skin attempts
to heal the break quickly and special immune cells on the skin attack invading germs.
We also have a second kind of protection called adaptive (or active) immunity.
This type of immunity develops throughout our lives. Adaptive immunity involves the
lymphocytes (as in the process described above) and develops as children and adults
are exposed to diseases or immunized against diseases through vaccination.
Passive immunity is "borrowed" from another source and it lasts for a short time.
For example, antibodies in a mother's breast milk provide an infant with temporary
immunity to diseases that the mother has been exposed to. This can help protect the
infant against infection during the early years of childhood.
Everyone's immune system is different. Some people never seem to get infections,
whereas others seem to be sick all the time. As people get older, they usually become
immune to more germs as the immune system comes into contact with more and more of
them. That's why adults and teens tend to get fewer colds than kids — their
bodies have learned to recognize and immediately attack many of the viruses that cause
Things That Can Go Wrong With the Immune System
Disorders of the immune system can be broken down into four main categories:
immunodeficiency disorders (primary or acquired)
autoimmune disorders (in which the body's own immune system attacks its own tissue
as foreign matter)
allergic disorders (in which the immune system overreacts in response to an antigen)
cancers of the immune system
Immunodeficiencies (pronounced: ih-myoon-o-dih-FIH-shun-seez) happen when a part
of the immune system is not present or is not working properly.
Sometimes a person is born with an immunodeficiency — these are called primary
immunodeficiencies. (Although primary immunodeficiencies are conditions that a person
is born with, symptoms of the disorder sometimes may not show up until later in life.)
Immunodeficiencies also can be acquired through infection or produced by drugs.
These are sometimes called secondary immunodeficiencies.
Immunodeficiencies can affect B lymphocytes, T lymphocytes, or phagocytes. The
most common immunodeficiency disorder is IgA deficiency, in which
the body doesn't produce enough of the antibody IgA, an immunoglobulin found primarily
in the saliva and other body fluids that help guard the entrances to the body. People
with IgA deficiency tend to have allergies or get more colds and other respiratory
infections, but the condition is usually not severe.
Acquired (or secondary) immunodeficiencies usually develop after a person has a
disease, although they can also be the result of malnutrition, burns, or other medical
problems. Certain medicines also can cause problems with the functioning of the immune
Acquired (secondary) immunodeficiencies include:
HIV (human immunodeficiency virus) infection and AIDS (acquired immunodeficiency
slowly and steadily destroys the immune system. It is caused by HIV, a virus which
wipes out certain types of lymphocytes called T-helper cells. Without T-helper cells,
the immune system is unable to defend the body against normally harmless organisms,
which can cause life-threatening infections in people who have AIDS.
Newborns can get HIV infection from their mothers while in the uterus, during the
birth process, or during breastfeeding. Teens and adults can get HIV infection by
having unprotected sexual intercourse with an infected person or from sharing contaminated
needles for drugs, steroids, or tattoos.
Immunodeficiencies caused by medications. Some medicines suppress
the immune system. One of the drawbacks of chemotherapy treatment for cancer, for
example, is that it not only attacks cancer cells, but other fast-growing, healthy
cells, including those found in the bone marrow and other parts of the immune system.
In addition, people with autoimmune disorders or who have had organ transplants may
need to take immunosuppressant medications. These medicines can also reduce the immune
system's ability to fight infections and can cause secondary immunodeficiency.
In autoimmune disorders, the immune system mistakenly attacks the body's healthy
organs and tissues as though they were foreign invaders.
Some autoimmune diseases include:
Lupus is a chronic
disease marked by muscle and joint pain and inflammation. The abnormal immune response
may also involve attacks on the kidneys and other organs.
idiopathic arthritis is a disease in which the body's immune system acts
as though certain body parts such as the joints of the knee, hand, and foot are foreign
tissue and attacks them.
Scleroderma is a chronic autoimmune disease that can lead to
inflammation and damage of the skin, joints, and internal organs.
Ankylosing spondylitis is a disease that involves inflammation
of the spine and joints, causing stiffness and pain.
Juvenile dermatomyositis is a disorder marked by inflammation
and damage of the skin and muscles.
Allergic disorders happen when the immune system overreacts when exposued to antigens
in the environment. The substances that provoke such attacks are called allergens.
The immune response can cause symptoms such as swelling, watery eyes, and sneezing,
and even a life-threatening reaction called anaphylaxis. Taking medications called
antihistamines can relieve most symptoms.
Allergic disorders include:
Asthma, a respiratory
disorder that can cause breathing problems, frequently involves an allergic response
by the lungs. If the lungs are oversensitive to certain allergens (like pollen, molds,
animal dander, or dust mites), it can trigger breathing tubes in the lungs to become
narrowed and swollen, leading to reduced airflow and making it hard for a teen to
Eczema is an
itchy rash also known as atopic dermatitis. Although atopic dermatitis is not necessarily
caused by an allergic reaction, it more often happens in kids and teens who have allergies,
hay fever, or asthma or who have a family history of these conditions.
Allergies of several types can happen in teens. Environmental
allergies (to dust mites, for example), seasonal allergies (such as hay fever), drug
allergies (reactions to specific medications or drugs), food
allergies (such as to nuts), and allergies to toxins (bee stings, for example)
are the common conditions people usually refer to as allergies.
Cancers of the Immune System
Cancer happens when cells grow out of control. This can also happen with the cells
of the immune system. Leukemia, which involves abnormal overgrowth
of leukocytes, is the most common childhood cancer. Lymphoma involves the lymphoid
tissues and is also one of the more common childhood cancers. With current medications
most cases of both types of cancer in kids and teens are curable.
Although immune system disorders usually can't be prevented, you can help your
immune system stay stronger and fight illnesses by staying informed about your condition
and working closely with the doctor.
And if you're lucky enough to be healthy, you can help your immune system keep
you that way by washing your hands
often to avoid infection, eating right, getting plenty of exercise, and getting
regular medical checkups.