Methotrexate

(meth oh TREKS ate)

What key warnings do I need to know about before giving this drug to my child?

• Your child's bone marrow, liver, lung, and kidney function will be watched closely.
• This drug may cause very bad infections, very bad skin side effects, and mouth sores.
• Talk with your child's doctor before giving your child any pain drugs (eg, ibuprofen, ketoprofen, naproxen). Your child's doctor will talk with you about the good effects and bad effects and your child will be closely watched while taking this drug.
• Sometimes drugs are not safe when your child takes them with other drugs. Taking them together can cause bad side effects. This is one of those drugs. Be sure to talk to your child’s doctor about all the drugs your child takes.

Is it safe for my child to take this drug?

• Not if your child has an allergy to methotrexate or any other part of this drug.
• Be sure to let the doctor know if your child has any allergies or side effects to drugs, foods, or dyes. Make sure to tell about the allergy and what signs your child had. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
• Not if your child has any of these health problems: Bone marrow disease, very bad liver disease, low blood cell count, or poor kidney function.
• Not if your child has a sunburn.

Why does my child need this drug?

• It is used to treat arthritis.
• It is used to treat leukemia.
• It is used to treat lymphoma.
• It is used to treat cancer.
• It is used to treat psoriasis.
• It is used to treat inflammatory bowel disease.
• It is used to stop graft-versus-host-disease.

How is this drug given?

• Oral:
• Follow how to give this drug as you have been told by your child's doctor. Do not give more than you were told to give.
• If your child is taking this drug by mouth, it is most often only given once a week. Talk with your child's doctor to make sure the dose is right.
• Give on an empty stomach.
• Shot:
• It is given as a shot into a muscle, vein, or into the fatty part of the skin.
• It is given as an infusion into a vein over a period of time.
• Your child's doctor may teach you how to give the shot.
• This drug may be given as a shot into the spinal fluid.

What do I do if my child misses a dose?

• Oral:
• Give a missed dose as soon as you think about it.
• If it is close to the time for your child's next dose, skip the missed dose and go back to your child's normal time.
• Do not give 2 doses or extra doses.
• Do not change the dose or stop your child's drug. Talk with your child's doctor.

What safety measures do I need to take when my child is using this drug?

• If your child has had hepatitis, talk with the doctor.
• If your child has kidney disease, talk with the doctor.
• If your child has liver disease, talk with the doctor.
• If your child has mouth sores, stomach irritation, or ulcers, talk with the doctor.
• If your child has a weak immune system, gets infections easy, or is on antibiotics, talk with your child's doctor.
• Have your child's blood work checked. Talk with your child's doctor.
• Check all drugs your child is taking with your child's doctor. This drug may not mix well with some other drugs.
• Keep a list of all your child's drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your child's doctor.
• When taking methotrexate for a long time or at high doses, your child may need closer watching of liver and bone marrow function. Talk with the doctor.
• Talk with the doctor before your child gets any vaccines. Use with this drug may either raise the chance of very bad infection or make the vaccine not work as well.
• Your child may get sunburned more easily. Avoid lots of sun, sunlamps, and tanning beds. Use sunscreen and dress your child in clothing and eyewear that protects him/her from the sun. Keep protecting your child from sunburn for at least a month after using this drug.

What are some side effects of this drug?

• Your child may have more chance of getting infections. Avoid crowds and people with infections, colds, or flu.
• Upset stomach or throwing up. Many small meals and good mouth care may help. Older children may suck hard, sugar-free candy. Your child may be given drugs to avoid these signs.
• Loose stools (diarrhea).
• Headache.
• Not hungry.
• Mouth irritation or sores. Using a soft toothbrush or cotton swabs and rinsing the mouth may help. Do not use mouth rinses that have alcohol in them.
• Sore throat.
• Hair loss. Hair most often grows back when this drug is stopped.
• Kidney failure may rarely happen.
• Harm to the liver may rarely happen.
• Harm to the lungs may rarely happen.
• Anemia, low white blood cell count, and low platelet count may rarely happen.

When do I need to call my child's doctor?

• If any of this news causes you to be worried or if any of the unwanted side effects happen after your child is given this drug.
• If you think there has been an overdose, call 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room (ER) right away.http://www.aapcc.org), or emergency room (ER) right away.
• If your child shows signs of a very bad reaction, call your child's doctor or the ER right away. These include wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; swelling of face, lips, tongue, or throat; or if your child is not acting normal.
• If your child shows any signs of infection. These include a fever of 100.5°F (38°C) or higher, chills, very bad sore throat, ear or sinus pain, cough, more sputum or change in color or sputum, pain with passing urine, mouth sores, wound that will not heal, or anal itching or pain.
• If your child has chest pain or pressure or a fast heartbeat.
• If your child has trouble breathing.
• If your child has pinpoint red spots on his/her skin.
• If your child is feeling very tired or weak.
• If your child has very bad belly pain.
• If your child has a very bad upset stomach or is throwing up.
• If your child has very loose stools (diarrhea).
• If your child has a cough that does not go away.
• If your child has mouth sores.
• If your child is not able to eat.
• If your child has dark urine or yellow skin or eyes.
• If your child has any bruising or bleeding.
• If your child gets a rash.
• If your child’s health problem does not get better or if you believe your child’s health problem is worse.

How do I store and/or throw out this drug?

• Oral:
• Store at room temperature.
• Store in a dry place. Do not store in a bathroom.
• Protect from light.
• Shot:
• Follow how to store the shot closely. Talk with the doctor.

General drug facts

• If your child has a very bad allergy, he/she needs to wear an allergy ID at all times.
• You may get this drug by drug order only. If there are refills, call your pharmacy. If your child does not have refills left, you may need to call your child's doctor.
• Get rid of this drug when your child no longer needs it or if the drug is outdated.
• If you have any questions about this drug, please talk with your doctor, pharmacist, or other health care provider.
• In Canada, take any unused drugs to the pharmacy. Also, visit http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/disposal-defaire-eng.php#th to learn about the right way to get rid of unused drugs.http://www.hc-sc.gc.ca/hl-vs/iyh-vsv/med/disposal-defaire-eng.php#th to learn about the right way to get rid of unused drugs.
• Do not share your child's drug with others and do not give anyone else's drug to your child.
• Keep all drugs out of the reach of children and pets.
• Keep a list of all your child's drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your child's doctor.
• These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
• Talk with the doctor before giving your child any new drug, including OTC, natural products, or vitamins.
• If you do not use a drug the right way, it may not be safe. Follow what your child’s doctor tells you.

This information should not be used to decide whether or not to take this medicine or any other medicine. Only your healthcare provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your healthcare provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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